In fact, it has been shown that regulation of VEGF production via this mechanism is more potent in comparison to transcriptional control. Cell surface nucleolin could shuttle ligands between the cell surface and the nucleus thus acting as a mediator for the extracellular regulation of nuclear events. In addition, accumulating data suggest that nucleolin binds other proteins such as the glucocorticoid receptor and protein tyrosine phosphatase-sigma and affects their activities. In the present study we demonstrate that the 212 C-terminal amino acids of nucleolin are sufficient to induce ErbB1 phosphorylation and dimerization. A dynamic equilibrium between tubulin subunits and assembled microtubules is the mechanism for microtubule assembly in vitro and in mitosis/meiosis, intracellular transport, cell motility, and cell shape. Microtubule assembly is GTP-dependent and carefully regulated by post-translational modification, ion concentrations, pH, calcium, phosphorylation, microtubule associated proteins and tubulin binding reagents. Hyperphosphorylation of the protein tau, a MAP linked with neurodegeneration, promotes destabilization of microtubules in Alzheimer’s disease which makes MAPs promising targets for therapeutic approaches to Alzheimer’s disease. Anti-mitotic drugs that disrupt the dynamic equilibrium of microtubules can be used in the treatment of cancer. The dynamic equilibrium is not Cycloheximide Small Molecules inhibitor limited to the mechanism for microtubule assembly. The self assembly of filament proteins including actin, viral coat proteins and spherical complexes of mammalian small heat shock proteins are dynamic equilibria suggesting the fundamental importance of dynamic equilibria in self assembly of numerous cellular macromolecules. Importantly, it is demonstrated that ErbB1 and 212-C-ter nucleolin co-localize on the cell surface. Moreover this interaction is functional as it is sufficient to increase growth in soft agar. Taken together our results, we suggest that the 212 C-terminal amino acids of nucleolin bind to the NLS of ErbB1 on the cell surface. Carabelli trait has figured prominently in the literature of human dental morphology. Our findings shed light on the phenotypic pattern of Carabelli trait expression. Carabelli, like many features of dental morphology exhibit a ”quasi-continuous” mode of variation or ”threshold dichotomy”. Such traits do not form below a ”physiological threshold” or ”phenotypic realization threshold” but vary continuously along a range of expression once the threshold is exceeded. Our data suggest that the patterning cascade model is the developmental mechanism that underlies the observed phenotypic expression of Carabelli. Asymmetry in grades of Carabelli trait expression and intercusp distance, each observed separately, align well with the expectations of the patterning cascade model.