We have developed large, diverse libraries of Abdurin binders and formatted these libraries for both phage and cell-free DNA display using CIS display. The Abdurin libraries were used to screen for specific binders to the extracellular domain of EphA2. A panel of high affinity Abdurin binders were isolated and characterized that recognize both murine and human EphA2 with low nM affinities. These binders are specific to the EphA2 receptor, readily internalized into cells and can specifically target EphA2-expressing tumors in a human prostate cancer xenograft model. Abdurins may offer certain advantages over monoclonal antibodies or other approaches for targeting tumors with imaging NPS-2143 agents or delivering cytotoxic pay loads due to their smaller size and prolonged half-life. In recent years pediatricians have warned of a previously underappreciated injury to the cerebellum in extremely premature infants and in those suffering from birth asphyxia. Prematurity and/or hypoxia-ischemia in the perinatal period are among the risk factors underlying cerebral palsy, a condition known to derive from developmental disturbances to the immature brain that lead to substantial motor, cognitive, and learning deficits. The pathophysiology of perinatal encephalopathy is difficult to study in the human, thus the neonatal rat model of hypoxicischemic brain injury has been useful in the analysis of this condition, considering that human brain development in late gestation seems to be equivalent to the Vinorelbine immediate postnatal stage in rats and mice. The intensive application of the Rice and Vannucci model of hypoxia-ischemia in the 7-day old rat has established several classic concepts with regards to immature brain vulnerability to selective neuronal death in major brain structures. Defective brain development or damage to motor areas during critical periods of organogenesis further disrupts the brain��s ability to adequately control movement and posture. In the preterm/ term fetus, umbilical cord compression often results in nearly complete asphyxia, leading to preferential injury to the periRolandic cortex, putamen and thalamus.