Advising of the increased risk of cerebrovascular events and death in patients with dementia treated with antipsychotic agents. Nevertheless, the practice of prescribing antipsychotics to elderly patients has continued and risperidone, the only SGA with an official indication for behavioural disturbances of dementia in Canada as well as in Europe and the US, remains the antipsychotic agent most commonly prescribed to the over-65 age group. The superiority of SGAs in terms of lower incidence of movement disorders or EPS such as acute dystonia, akathisia, parkinsonism and tardive dyskinesia, has been recently challenged. The current study was designed to evaluate in a real world setting the incidence of movement disorders in the entire population of elderly residents of a Canadian province treated for various diagnoses with either risperidone or an FGA. This study provides data on the incidence of EPS adverse events in the entire elderly population of the Canadian province of Manitoba treated with antipsychotic pharmacotherapy. More than 70% of the population initiated on a SGA was prescribed risperidone. Our results show that the use of FGAs is associated with an increased risk of EPS compared to treatment with risperidone. These results are supported by biological plausibility and are consistent with the findings of previous observational studies.We here provide a structural explanation for the observed switch in oligomerization state of the cortexillin-1 AbMole Dimesna coiled coil from a dimer to a trimer and further generalize the relationship between coiled-coil oligomerizationstate specificity and trigger-sequence function. Our study therefore represents a confirmation and extension of existing sequence-tostructure rules. Such detailed information on coiled-coil sequence-to-structure rules should be beneficial for retrospective interpretation of existing results and could form a basis for design of new molecular entities. A well-documented example is the application of a coiled coilbased strategy for the investigation of the activation mechanisms of prokaryotic and eukaryotic transmembrane receptors. These studies have shown that dimerization is not always sufficient to induce autophosphorylation and that additional conformational changes such as, for example, rotation of the kinase domains relative to each other are required for activation. A coiled-coil based approach has been used to test the dimerization-rotation model for several homodimeric proteins. Typically, the extracellular domain of a given receptor is replaced by the short dimeric coiled coil of the S. cerevisiae transcription factor Put3 and fused to its transmembrane domain and intracellular domain. By removing residues of the transmembrane domain at the junction to the coiled coil, designed variants with seven different rotational conformations of the cytosolic domains relative to each other were generated by imposing the Put3 heptad-repeat pattern. However, in some cases the Put3 coiled coil might not be stable or specific enough to impose the conformations on the transmembrane domain and/or the cytoplasmic domain.