A more detailed scientific validation of the texture analyses is necessary, of course. Data from genome-wide methylation or chromatin analyses should be compared with fractal data derived from digitalized images of routinely stained tumor smears or sections,Niraparib in order to define better the equivalence between changes of the image texture and genome-wide biochemical chromatin changes. Since there is a vast heterogeneity of molecular profiles among myeloma patients, detailed individual genomic evaluations for targeted therapies seem not to be helpful at the moment, as has been emphasized recently. In this situation, a global evaluation of the nucleus, as presented in this investigation, could be interesting. This technique is simple, reproducible and unexpensive and may be applied to routine slides from the files, thus permitting retrospective studies without any additional costs. Therefore,AMN107 we think it could be useful in daily routine practice in future. But since our study was based on a relatively small number of patients, it should, of course, be followed by confirmatory investigations based on more and new patients in different centers. Adverse drug reactions represent a major burden on the healthcare system, and are a common cause of hospital admission as well as of in-hospital morbidity and mortality. Chronic kidney disease patients are particularly vulnerable to ADRs because they are usually on multiple drug regimens, have different comorbid conditions, and because of alteration in their pharmacokinetics and pharmacodynamic parameters. Therefore, one important step towards reducing ADRs is to identify those patients who are at increased risk of an ADR and to address their individual risk factors. Differences in individual genome can be considered as predictors for an ADR, however high cost and lack of laboratory facilities limit their applicability in daily clinical practice. Another method is to develop a clinical tool or a risk assessment scale for identifying high-risk patients.