ADM has been identified as a highly connected gene in the dependency network with marked difference under cancer and control condition. Literature mining analysis has identified it to be significantly associated with four out of the five cancer hallmarks considered in the current study. ADM is a research target for various cancers, and its significant differential expression in our study dataset suggests it to be one of the most potential therapeutic targets for oral cancer. TP53 is a potent tumor suppressor gene which is known to be under-expressed in various AT-56 malignancies, including oral cancer. TP53 was detected in our study to be significantly under expressed gene, and was found to be involved in key hallmark events like apoptosis, angiogenesis and cell proliferation. It was detected to be well connected gene with marked topological difference in the dependency network under cancer and control condition. The ability to regulate cancer via multiple pathways makes TP53 as one of the potential therapeutic targets for oral cancer. Literature mining analysis and mining of TTD has identified TP53 as a therapeutic marker for various cancers including those of oral cavity. Connectivity tissue growth Golgicide A factor was identified as a therapeutic target by literature mining analysis and was detected to be significantly involved in key hallmark events like angiogenesis and cell proliferation. CTGF shows marked topological difference in the dependency network under cancer and control condition making it one of the potential therapeutic targets for oral cancer. Epidermal growth factor receptor which is incidentally a successful molecular target for oral cancer, has been also detected as a potential therapeutic target in the current study. EGFR was identified as well connected gene in dependency and causal network, and was detected as a significant hypothesis by causal reasoning analysis. CTLA4 was another potential therapeutic target identified in the current study. Literature mining analysis significantly associated it with apoptosis and cell-proliferation. CTLA4 has been reported to regulate key genes involved in carcinogenesis like STAT1, NFATC2, c-Fos, cMyc, and/or Bcl-2. Literature mining analysis and mining of TTD have identified CTLA4 as a therapeutic marker for various cancers. CD70 was identified as a potential anti-body based therapeutic target.