From these 10 gene-sets, a single gene-set from the White population was able to predict disease outcomes across all scoring criteria. This particular gene set did not exhibit any predictive value when analyzed against the African-American cohort of samples. The African-American gene-set was only able to predict disease Clofentezine outcome using the combined criteria. All other gene-sets, from all population groups, were able to predict survival outcomes for only one scoring criteria. Furthermore, these predictive clusters were shared between all the hormones, supporting the results from our dynamic modeling study, where the T877A mutation accommodates all steroid hormones to and exhibits very subtle structural differences, although the overall structures appear to elicit the same functional interaction platform. A similar analysis to that performed with our proteomic data was performed using our LNCaP multi-panel hormone TPPB microarray gene expression data across our hormone stimulation conditions. We selected 10, 20, 50 and 100 of the most variably expressed genes from our microarray data set to assess the ability to predict disease progression and outcome between White or African-American men. We identified two gene-sets of 10 and 50 genes respectively that were able to distinguish between normal vs. tumor in White men, but not African-American men. There appears to be no predictive value associated with each different class of hormone stimulation, irrespective of whether the hormones act through T877A-AR or through their cognate receptor. It is also apparently clear that the two different data-sets, result in two different capabilities of predicting disease outcomes. This is a direct result of linking ontological function to a specific protein sub-network vs. arbitrarily selecting a defined number of genes linked solely to expression profiles. Finally, although LNCaP cells are derived from a metastatic CaP lymph-node biopsy from a White male, other cell lines also possessing the T877A-AR mutation, MDA-PCa-2a and MDA-PCa-2b, from bone metastatic CaP from African American also exist.